Journal: Biomedicines
Article Title: Augmented Ouabain-Induced Vascular Response Reduces Cardiac Efficiency in Mice with Migraine-Associated Mutation in the Na + , K + -ATPase α 2 -Isoform
doi: 10.3390/biomedicines11020344
Figure Lengend Snippet: Temporal alignment between the second time derivative of aortic blood flow, ECG, and blood pressure traces allowed for the calculation of systolic time intervals. Upper panel includes blood flow through the ascending aorta (black line) and its 2nd time derivative, i.e., acceleration (gray line). Lower panel includes mouse ECG lead I with depicted Q, R, and S waves (black line) together with arterial blood pressure measured in the aortic arc (gray line). Black arrow indicates the dicrotic notch on the blood pressure trace, i.e., closure of the aortic valve. Preejection period was defined as spanning from the beginning of the Q wave to opening of the aortic valve, i.e., Q wave to the first peak of the second time derivative of aortic flow. Left ventricular ejection period was defined as spanning from the opening to the closure of the aortic valve, i.e., spanning from the first peak of the second time derivative of blood flow to the dicrotic notch. Systolic duration was defined as the sum of the pre-ejection period and left ventricular ejection time.
Article Snippet: Electrocardiogram (ECG) leads I and II were recorded with electrodes on the paws (MLA2505, ADInstruments, Sydney, Australia).
Techniques: